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目的 比较孤独症儿童和正常儿童血浆5-羟色胺(5-HT)的浓度,探索5-HT浓度增高和5-HT浓度正常的孤独症儿童各自的临床特点。方法 采用孤独症行为评定量表(ABC)、儿童期孤独症评定量表(CARS)和适应行为评定量表对33例孤独症儿童进行评定,并进行了血浆5-HT检测,以高出正常儿童平均5-HT浓度1.67个标准差的孤独症儿童为5-HT增高组,其他孤独症儿童为5-HT正常组,比较两组孤独症儿童的临床特征。结果 孤独症儿童的ABC得分为72.30±29.91、CARS的得分为41.83±4.05、适应行为评定量表的得分为66.55±12.52。孤独症儿童5-HT浓度为0.77±0.33μmol/L;正常儿童5-HT浓度为0.62±0.18μmol/L,两组经t检验有显著性差异(t=2.23;P=0.03)。5-HT增高的孤独症儿童有9例,5-HT正常的孤独症儿童有24例,两组临床特征比较未发现明显差异。结论 27.3％的孤独症儿童5-HI浓度增高,5-HT增高与5-HT正常的儿童孤独症临床特征相同。孤独症的病因可能是异质性的。
Objective To compare the plasma concentrations of 5-hydroxytryptamine (5-HT) in children with autism and normal children and to explore the clinical features of children with autism whose 5-HT levels are elevated and their 5-HT concentrations are normal. Methods 33 cases of autistic children were evaluated by autistic behavior assessment scale (ABC), childhood autism assessment scale (CARS) and adaptive behavior assessment scale, and plasma 5-HT was detected to be higher than normal Children with an average 5-HT concentration of 1.67 standard deviation of autistic children as 5-HT increased group, other children with autism 5-HT normal group, the clinical features of children with autism in both groups were compared. Results Children with autism had an ABC score of 72.30 ± 29.91, a CARS score of 41.83 ± 4.05, and a score of 66.55 ± 12.52 on the Adaptation Behavior Rating Scale. The concentration of 5-HT in children with autism was 0.77 ± 0.33μmol / L and that of normal children was 0.62 ± 0.18μmol / L. The t-test showed significant difference (t = 2.23; P = 0.03). There were 9 autistic children with elevated 5-HT, 24 autistic children with normal 5-HT, and no significant difference was found between the two clinical features. Conclusions 27.3% of children with autism have higher concentrations of 5-HI and 5-HT have the same clinical features as autistic children with normal 5-HT. The cause of autism may be heterogeneous.