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肌腱作为骨骼和肌肉的连接往往容易受到损伤,目前对肌腱基本生物学有限的了解妨碍了肌腱修复技术的发展。最近,一系列肌腱生长相关因子被发现,其中Scleraxis(Scx)和Mohawk(Mkx)已被确定为肌腱生长和分化中的关键转录因子,Sox9和EGR1/2也被报道参与肌腱的生长。然而,目前研究尚未明确这些转录因子的生物学功能及其分子机制。本文就上述转录因子的分布与功能,及转录因子相关分子进行综述,为肌腱的修复提供生物学基础并探讨肌腱损伤治疗的未来发展方向。
Tendons, as the connection between bones and muscles, tend to be easily damaged, and currently limited understanding of tendon basic biology hinders the development of tendon repair techniques. Recently, a series of factors related to tendon growth were found, of which Scleraxis (Scx) and Mohawk (Mkx) have been identified as key transcription factors in tendon growth and differentiation, and Sox9 and EGR1 / 2 have also been reported to be involved in tendon growth. However, at present, the biological function of these transcription factors and their molecular mechanisms have not been elucidated yet. This review summarizes the distribution and function of these transcription factors and the related transcription factors and provides the biological basis for the repair of tendons and explores the future development of tendon injury treatment.