【摘 要】
：
We used a rat pheochromocytoma (PC12) cell line to study the effects of salidroside on hydrogen peroxide (H2O2)-induced apoptosis. In PC12 cells, H2O2-induced a
【机 构】
：
School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China“,”Yang
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We used a rat pheochromocytoma (PC12) cell line to study the effects of salidroside on hydrogen peroxide (H2O2)-induced apoptosis. In PC12 cells, H2O2-induced apoptosis was accompanied by the down-regulation of Bcl-2, the upregulation of Bax, the release of mitochondrial cytochrome c to cytosol, and the activation of caspase-3, -8 and -9. However,salidroside suppressed the down-regulation of Bcl-2, the upregulation of Bax and the release of mitochondrial cytochrome c to cytosol. Moreover, salidroside attenuated caspase-3, -8 and -9 activation, and eventually protected cells against H2O2-induced apoptosis. Taken together, these results suggest that treatment of PC12 cells with salidroside can block H2O2-induced apoptosis by regulating Bcl-2 family members and by suppressing cytochrome c release and caspase cascade activation.
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