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目的:分析Cervista检测中各人乳头瘤病毒(HPV)型对不同级别宫颈病变诊断的临床意义。方法:选取我院2014年2月-2015年1月就诊女性8984例为初筛对象,进行阴道镜和组织病理学活检,检测HPV。比较HPV各型在不同级别宫颈病变中的阳性检出率,分析HPV各型在不同级别宫颈病变筛检中的灵敏度、阴性预测值指标。结果:宫颈上皮内瘤变(CIN)2+级别中,A9型组HPV感染率高于A5/A6和A7型组。在CIN3+级别中,A9型组HPV感染率高于A5/A6和A7型组。结论:Cervista检测中的A9型组阳性对诊断CIN2+及CIN3+级别宫颈病变的一定临床意义。
Objective: To analyze the clinical significance of Cervista in the diagnosis of cervical lesions of different grades. Methods: A total of 8984 female patients in our hospital from February 2014 to January 2015 were selected as primary screening subjects for colposcopy and histopathology biopsy to detect HPV. The positive rate of HPV in different types of cervical lesions was compared. The sensitivity and negative predictive value of HPV in different levels of cervical lesions were analyzed. Results: In the cervical intraepithelial neoplasia (CIN) 2+ level, HPV infection rate in A9 group was higher than that in A5 / A6 and A7 groups. In the CIN3 + class, HPV infection rates in the A9 group were higher than those in the A5 / A6 and A7 groups. Conclusion: A9-positive group in Cervista test is of clinical significance for the diagnosis of cervical lesions of CIN2 + and CIN3 + levels.