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20世纪60年代初期喹诺酮类已广泛用于许多细菌性感染的治疗,而较老的喹诺酮类从未获得过如此广泛的应用。在最近几年,由于氟喹诺酮类的发展已完全改变了喹诺酮类的地位。今天,用于临床的这些氟喹诺酮类,主要是由于它们有优异的抗菌活性和药代动力学性质。在联邦德国,氟喹诺酮类处方数由1985年的31万张(氟哌酸),到1988年增至143万9千张(氟哌酸、氟嗪酸、环丙氟哌酸、氟啶酸)。这些数据还不包括这类抗菌剂在各医院中的使用数。使用的增加,治疗中的不良反应经常有报道,关于喹诺酮类的安全性问题更是常被提及。至于这类药物毒性的危险性和各种副
Quinolones have been widely used in the treatment of many bacterial infections in the early 1960s, while older quinolones have never been so widely used. The development of fluoroquinolones has completely changed the status of quinolones in recent years. Today, these fluoroquinolones for clinical use are mainly due to their excellent antibacterial and pharmacokinetic properties. In the Federal Republic of Germany, the number of fluoroquinolones prescriptions increased from 310,000 (norfloxacin) in 1985 to 1.43 million in 1988 (norfloxacin, trifloxysin, ciprofloxacin, fipronil) . These data do not include the use of such antibacterials in various hospitals. Increased use, adverse reactions to treatment are often reported, and safety concerns with quinolones are more often mentioned. As for the toxicity of these drugs and a variety of dangerous vice