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本文研究了[竹叶黄酮(BLF)+决明子粉(CSF)=16:9]与维生素C棕榈酸酯(AP)、维生素E琥珀酸酯(α-TOS)的体外抗氧化活性,并考察了不同配比组方调节高血脂大鼠脂质代谢及其抗氧化应激的能力。[BLF+CSF]与AP组合(5:1)的体外抗氧化协同增效作用显著强于[BLF+CSF]与α-TOS组合(5:1);[BLF+CSF]与AP、α-TOS组合(5:1:1)协同增效效果最为显著,表现出最强的体外抗氧化能力。构建高脂血大鼠模型,并评价不同组合物降脂和抗氧化应激能力,结果表明各组方均能够调节高脂血症大鼠的脂质代谢,提高其抗氧化应激能力。其中,[BLF+CSF]与AP和α-TOS(5:1:1)协同增效调节脂质代谢和抗氧化应激效果最为显著,可协同增效显著降低动脉粥样硬化指数(p<0.01),调控血脂:降低TC(p<0.01)、TG(p<0.01)、LDL-c(p<0.01),显著升高HDL-c(p<0.01)。在体内抗氧化应激能力上:显著提高血清T-AOC(p<0.01),显著增加SOD活性(p<0.01)、GSH-Px活性(p<0.01),降低MDA(p<0.01)。
In this paper, the in vitro antioxidant activities of [BLF + MSG = 16: 9] and vitamin C palmitate (AP) and vitamin E succinate (α-TOS) Regulation of Lipid Metabolism and Antioxidative Stress Ability in Hyperlipidemic Rats by Different Mixture Prescriptions. The synergistic effect of [BLF + CSF] and AP combination (5: 1) in vitro was significantly stronger than the combination of [BLF + CSF] and α-TOS TOS combination (5: 1: 1) synergistic effect of the most significant, showing the strongest antioxidant capacity in vitro. The rat model of hyperlipidemia was constructed, and the lipid-lowering and anti-oxidative stress ability of different compositions were evaluated. The results showed that each group could regulate the lipid metabolism of hyperlipidemic rats and enhance their anti-oxidative stress ability. Among them, [BLF + CSF] synergistically regulates lipid metabolism and antioxidant stress with AP and α-TOS (5: 1: 1), and synergistically significantly decreases atherosclerosis index (p < 0.01). The level of HDL-c in HDL-c was significantly higher than that in control group (P <0.01), TC (p <0.01), LDL-c (p <0.01) Antioxidant capacity in vivo: The serum T-AOC level increased significantly (p <0.01), SOD activity increased significantly (p <0.01), GSH-Px activity decreased (p <0.01) and decreased MDA (p <0.01).