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生长抑素(Somatostatin,SS)是一种由14个氨基酸组成的脑肠肽。近年来的研究发现,给予外源性SS可防止应激和无水乙醇等所致的胃粘膜损伤。然而,SS与胃粘膜适应性细胞保护的关系,尚未见报道。我们和Robert等的工作表明,预先用胃内持续存在的天然弱刺激(胃蛋白酶溶于生理浓度盐酸)或外源性弱刺激(如20％酒精)灌胃,均对随后给予的各种坏死性物质所致的胃粘膜损伤具有适应性细胞保护作用。这种现象的产生机制之一,是由
Somatostatin (SS) is a ghrelin consisting of 14 amino acids. In recent years, studies have found that exogenous SS can prevent gastric mucosal damage caused by stress and ethanol. However, the relationship between SS and gastric mucosal adaptive cytoprotection has not been reported yet. Our work with Robert et al. Showed that prenatal administration of various natural necrotic stimuli (pepsin in physiological concentrations of hydrochloric acid) or exogenous weak stimuli (such as 20% alcohol) in advance in the stomach, Sexual substances caused by gastric mucosal injury with adaptive cytoprotection. One of the mechanisms by which this phenomenon occurs is by