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肾小球系膜细胞增生和硬化是多种病理类型肾炎的共同病理特征,大量临床和实验研究证明体内多种内分泌、旁分泌和自分泌的细胞因子或生长因子参与和调节肾小球系膜细胞增生和硬化。我们探讨内分泌代谢因素在肾小球硬化中的作用,应用细胞培养的方法研究了生长代谢类激素对系膜增殖及分泌纤维连结蛋白(FN)的影响作用,旨在探讨系膜增生的细胞生物学机制。 1 材料与方法
Glomerular mesangial cell proliferation and sclerosis is a common pathological features of various pathological types of nephritis, a large number of clinical and experimental studies have shown that a variety of endocrine, paracrine and autocrine cytokines or growth factors in vivo and regulate glomerular mesangial Cell proliferation and sclerosis. We explored the role of endocrine and metabolic factors in glomerulosclerosis. The effect of growth hormone metabolism on the proliferation and secretion of fibronectin (FN) in mesangial cells was investigated by cell culture in order to investigate the effects of mesangial cell proliferation Learning mechanism. 1 materials and methods