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目的:观察小儿康肾汤配合强的松及环磷酰胺三联疗法治疗小儿难治性肾病综合征的效果。方法:选取难治性肾病综合征患儿72例,随机分为两组,治疗组和对照组各36例,对照组给予标准剂量强的松和环磷酰胺,治疗组采用小儿康肾汤配合强的松及环磷酰胺三联疗法。观察两组治疗前后临床缓解率、24h尿蛋白定量、血清白蛋白、总胆固醇、肾功能等指标及复发率。结果:治疗组总缓解率91.7%,对照组75.0%(P<0.05);与治疗前比较,两组24h尿蛋白定量、血清白蛋白、总胆固醇均有好转(P<0.05,P<0.01),治疗后组间比较,治疗组好于对照组(P<0.05,P<0.01);治疗组1年内复发率5.56%,2年内复发率13.89%,对照组分别为22.22%和41.67%(P<0.01)。结论:小儿康肾汤配合强的松及环磷酰胺三联疗法治疗小儿难治性肾病综合征的疗效优于单纯西医疗法,且复发率低。
Objective: To observe the effect of Xiaoer Kangshen Decoction combined with prednisone and cyclophosphamide triple therapy in the treatment of refractory nephrotic syndrome in children. Methods: Seventy-two children with refractory nephrotic syndrome were randomly divided into treatment group (36 cases) and control group (36 cases). The control group was given the standard dose prednisone and cyclophosphamide. The treatment group Prednisone and cyclophosphamide triple therapy. Before and after treatment, the clinical remission rate, 24h urinary protein, serum albumin, total cholesterol, renal function and other indicators and recurrence rate were observed. Results: The total remission rate was 91.7% in the treatment group and 75.0% in the control group (P <0.05). Compared with those before treatment, the urinary protein excretion, serum albumin and total cholesterol in both groups were improved (P <0.05, P <0.01) , The treatment group was better than the control group (P <0.05, P <0.01). The recurrence rate of the treatment group was 5.56% in 1 year and 13.89% in 2 years respectively, while the control group was 22.22% and 41.67% respectively <0.01). Conclusion: The therapeutic effect of pediatric decoction combined with prednisone and cyclophosphamide triple therapy on refractory nephrotic syndrome in children is better than that of western medicine alone, and the recurrence rate is low.