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扩散抑制(Spreading depression,SP)最初是在麻醉动物皮质脑电图上所见到的一种缓慢的扩布性抑制,以后的研究发现它与偏头痛先兆的病理生理机制、缺血性卒中脑损伤的扩展有关。在动物模型中,SP能引起对缺血性卒中的耐受,动物和人头部外伤后均发现有SP存在。SP是头部局部血流、血管活动及与基因改变相关功能的长期变化的一种现象,除与局部的离子梯度和代谢有关外,它还可引起局部血流、软膜血管、C-fos基因含量、神经生长因子、神经胶质诱导纤维酸蛋白
Spreading depression (SP) was originally a slow spread of inhibition seen on the cortical electroencephalogram of anesthetized animals. Subsequent studies found that it is associated with the pathophysiology of migraine aura, ischemic stroke brain Damage related to expansion. In animal models, SP can cause tolerance to ischemic stroke, and SP is found in both animal and human head trauma. SP is a phenomenon of long-term changes of the local blood flow, the activity of the blood vessels, and the function related to the gene changes. In addition to the local ion gradient and metabolism, SP can cause local blood flow, soft membrane blood vessels, C-fos Gene content, Nerve growth factor, Glial induced fibrin acid protein