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应用酶联免疫吸附试验（ELISA）法检测75例糖尿病患者和40名正常人随意尿转铁蛋白／肌酐（Tf／Cr）的变化，观察到糖尿病患者Tf／Cr明显增加，且随着病变进展Tf／Cr改变更趋显著。82．6％糖尿病患者Tf／Cr升高，而尿白蛋白／Cr（Alb／Cr）仅64％升高，两组比较有显著差异。尿液Alb／Cr正常的糖尿病患者中，亦有60．7％Tf／Cr升高。尿液Tf／Cr与Abl／Cr、收缩压、舒张压是正相关，与空腹血糖、糖化血红蛋白、果糖胺无相关性。结果表明尿Tf／Cr测定可为临床诊断糖尿病性肾病提供了一个更为敏感的指标。
The urinary transferrin / creatinine (Tf / Cr) in 75 diabetics and 40 normal persons was detected by enzyme-linked immunosorbent assay (ELISA). The Tf / Cr in diabetic patients was significantly increased. With the progression of the disease Tf / Cr changes more pronounced. Tf / Cr increased in 82.6% of diabetic patients, while urinary albumin / Cr (Alb / Cr) increased only 64%. There was significant difference between the two groups. Urinary Alb / Cr in patients with normal diabetes, there are 60.7% Tf / Cr increased. Urine Tf / Cr and Abl / Cr, systolic blood pressure and diastolic blood pressure are positively correlated with fasting blood glucose, glycosylated hemoglobin, fructosamine no correlation. The results show that urinary Tf / Cr assay can provide a more sensitive index for the clinical diagnosis of diabetic nephropathy.