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目的探讨红细胞免疫促进因子、免疫抑制因子及T淋巴细胞亚群免疫黏附功能的变化及规律,为今后临床病情判定、预后的预测提供依据。方法选择脑出血患者及正常对照组进行红细胞C3b受体花环率(RBC-C3bRR)、红细胞免疫复合物花环率(RBC-ICR)、红细胞免疫促进因子(RFER)、红细胞免疫抑制因子(RFIR)以及T淋巴细胞亚群(CD3+、CD4+、CD8+)的测定,并比较两组结果的差异。此外,将患病组进行神经功能的损伤程度分层比较。结果病例组与对照组RBC-C3bRR、RBC-ICR、RFER及RFIR的差异有统计学意义(P﹤0.001);按照神经功能损伤程度分层后比较,不同损伤程度RBC-C3bRR、RBC-ICR、RFER及RFIR的差异也有统计学意义(P﹤0.01)。病例组与对照组CD3+、CD4+、CD8+及CD4/CD8的差异有统计学意义(P﹤0.01);按照神经功能损伤程度分层后比较,不同损伤程度CD3+、CD4+、CD8+及CD4/CD8的差异也有统计学意义(P﹤0.01)。结论脑出血患者的红细胞免疫促进因子、免疫抑制因子及T淋巴细胞亚群免疫功能较为低下,检测这些细胞学指标对判断病情,预后的预测有一定的指导意义。
Objective To investigate the changes and regularity of erythrocyte immune facilitation factor, immunosuppressive factor and T lymphocyte subsets immune adherence function, and to provide basis for the future clinical judgment and prognosis prognosis. Methods RBC-C3bRR, RBC-ICR, RFER and RFIR of erythrocyte C3b receptor were detected in patients with cerebral hemorrhage and normal controls. T lymphocyte subsets (CD3 +, CD4 +, CD8 +) were measured and the difference between the two groups was compared. In addition, the severity of neurological damage in the diseased group was stratified. Results The levels of RBC-C3bRR, RBC-ICR, RFER and RFIR in case group and control group were significantly different (P <0.001). According to the degree of neurological injury, RFER and RFIR differences were also statistically significant (P <0.01). The differences of CD3 +, CD4 +, CD8 + and CD4 / CD8 in case group and control group were statistically significant (P <0.01). The difference of CD3 +, CD4 +, CD8 + and CD4 / CD8 in different injury groups Also statistically significant (P <0.01). Conclusions The immune function of erythrocyte, immunosuppressive factor and T lymphocyte subsets in patients with intracerebral hemorrhage is relatively low. To detect these cytological indexes may be helpful to predict the prognosis of patients with cerebral hemorrhage.