论文部分内容阅读
目的:探讨盐酸氨溴索不同用药方式对早产儿肺透明膜病(HMD)的预防效果。方法:选取2012年1月至2014年12月我院收治的145例早产儿,按照给药方式不同分为4组,分别为静脉给药组、静脉雾化给药组、雾化给药组及对照组,通过监测血氧饱和度和第3天的X线胸片,比较各组HMD的发病率、胸片表现、血氧饱和度开始下降的时间及并发症的发生率。结果:静脉给药组和静脉雾化给药组HMD发病率、并发症的发生率、病情严重程度均低于对照组,血氧饱和度开始下降的时间晚于对照组,差异有统计学意义(P<0.05)。结论:盐酸氨溴索能有效预防HMD,降低HMD发病率及并发症的发生率,减轻病情严重程度,且静脉和静脉联合雾化给药效果优于单纯雾化给药。
Objective: To investigate the preventive effects of ambroxol hydrochloride on preoperative neonates with hyaline membrane disease (HMD). Methods: One hundred and forty-five preterm infants admitted from January 2012 to December 2014 in our hospital were divided into four groups according to the mode of administration: intravenous group, intravenous group and nebulized group And the control group, by monitoring the oxygen saturation and the third day of X-ray, comparing the incidence of HMD in each group, chest X-ray performance, oxygen saturation began to decline time and the incidence of complications. Results: The incidence of HMD, the incidence of complications and the severity of the disease were lower in the intravenous group and the intravenous nebulized group than those in the control group. The oxygen saturation began to decline later than the control group, with significant difference (P <0.05). Conclusion: Ambroxol hydrochloride can effectively prevent HMD, reduce the incidence of HMD and the incidence of complications, reduce the severity of the disease, and the combination of intravenous and intravenous nebulization is better than simple nebulized administration.