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利用RP-HPLC,以卡马西平(CZ)为内标,对国内3个厂家生产的双氯芬酸钠(D5)肠溶片进行了崩解度、释放度、含量测定的研究。结果表明:不同厂家的DS肠溶片释放度差异极为显著(P<0.01)、崩解度与释放度之间有较好的相关性(r=0.9103)。
The contents of disintegration, release and content of diclofenac sodium (D5) enteric-coated tablets produced by three domestic manufacturers were studied by RP-HPLC and CZ as internal standard. The results showed that there were significant differences in the release of DS enteric-coated tablets from different manufacturers (P <0.01), and good correlation between disintegration and release (r = 0.9103).