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目的 探讨大剂量１５３Ｓｍ－ＥＤＴＭＰ联合帕米磷酸二钠治疗骨转移癌的止痛效果。方法 ５１ 例确诊骨转移癌病人分成２组，其中治疗组３１例：应用１５３Ｓｍ－ＥＤＴＭＰ１８５０ ｍＢｑ静注１次，帕米磷酸二钠３０ｍｇ＋生理盐水５００ｍｌ，静滴，１／ｄ，连用３ｄ；对照组２０例：单用１５３Ｓｍ－ＥＤＴＭＰ１８５０ｍＢｑ治疗；每 ３～５个月重复 １次。结果联合治疗组病人生存时间延长：治疗组：（４５． ４ ± １０． ０）周，对照组（３７．４±１０．０）周（Ｐ＜０．０１）。治疗组止痛有效率１００％，对照组９０％（Ｐ＞０．０５）。两组副反应发生率无显著差异，未出现治疗相关死亡。结论联合治疗是有效的和安全的。
Objective To investigate the analgesic effect of high-dose 153Sm-EDTMP combined with pamidronate in the treatment of bone metastases. Methods 51 patients diagnosed with bone metastases were divided into 2 groups, including 31 patients in the treatment group: 153Sm-EDTMP 1850 mBq intravenously for 1 time, pamidronate 30 mg + normal saline 500 ml, intravenous infusion, 1/d for 3 days; control group 20 cases: single treatment with 153Sm-EDTMP1850mBq; repeated every 3 to 5 months. Results The survival time of patients in the combination therapy group was prolonged: treatment group: (45.4 ± 10.0) weeks, and control group (37.4 ± 10.0) weeks (P <0.01). The treatment group was 100% effective in pain relief and 90% in the control group (P>0.05). There was no significant difference in the incidence of adverse reactions between the two groups and no treatment-related deaths occurred. Conclusion Combination therapy is effective and safe.