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目的 观察吞服液性药物后不同时间点口腔、食管内的药物残留 ,讨论其意义。方法 10名健康受试者空腹口服 6 0mL含 1 85× 10 10 Bq99mTc -MIBI的药液 ,并禁食禁饮 ,以Toshiba 710 0A/DI旋转型γ照相机 ,于服药后即刻、0 5、1、2、3、4h分别前位采集图像 ,包括口腔、食管 ,以ROI技术获取不同时间点口腔、食管内放射性计数 ,计算口腔、食管内不同时间点放射性计数占服药后即刻放射性计数的百分比。结果 10名受试者口服99mTc药液 4h后仍可见口腔、食管显像 ,于服药后即刻、0 5、1、 2、 3、4h的口腔和食管内放射性计数均值分别为 6 980 5、2 14 0 6、736 0、4 4 0 0、32 5 3、2 5 5 9和 2 816 6、5 2 4 8、12 5 2、97 6、84 4、74 8,服药后 0 5、1、2、3、4h ,口腔和食管内共有 4 9 2 9%、14 99%、9 77%、7 6 6 %、6 33%的药物残留。结论 口服液性药物后较长时间内口腔、食管内都有药物残留 ,有重要临床意义。
Objective To observe the oral cavity and esophageal drug residues at different time points after swallowing liquid drugs and discuss its significance. Methods Ten healthy volunteers were orally administered with 60 mL liquid containing 1 85 × 10 10 Bq99mTc -MIBI and fasting forbidden to drink. Toshiba 710 0A / DI rotating gamma camera was used. Immediately after taking the medicine, 0 5, 1 , 2, 3, 4h, respectively. The images of oral cavity and esophagus were collected before and after oral administration. The radioactive counts of oral cavity and esophagus were obtained by ROI technique at different time points. The radioactive counts of oral cavity and esophagus at different time points were calculated. Results After oral administration of 99mTc solution for 10 months, the oral cavity and esophageal imaging were still visible. After oral administration, oral and esophageal radioactive counts at 0, 5, 1, 2, 3 and 4 hours were 6 980 5 and 2 14 respectively 0 6,736 0,4 4 0 0,32 5 3,2 5 5 9 and 2 816 6,5 2 4 8,12 5 2,97 6,84 4,74 8 After taking 0 5,1,2 , 3,4h, there were 49,229%, 14,99%, 9,77%, 76,6% and 633% of the drug residues in oral cavity and esophagus. Conclusion Oral liquid drugs for a long time after oral cavity, esophageal drug residues have important clinical significance.