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目的观察 6 7-KD层粘连蛋白受体 (6 7-KDlamininreceptor,6 7-KDLN -R)在人喉鳞癌细胞中的表达情况 ,并分析其表达与临床病理特征间的关系。 方法采用免疫组化SP方法检测 30例喉鳞癌原发灶和其中的 3例颈淋巴结转移灶石蜡标本中 6 7-KDLN -R的表达。 结果 6 7-KDLN -R在喉鳞癌原发灶中的阳性率为5 6 .7% (1 7/ 30 )。转移淋巴结的免疫反应结果与原发部位的免疫反应结果相一致。 6 7-KDLN -R的表达与肿瘤的分化程度密切相关 ,分化差者其表达水平更高 (P <0 .0 5 )。与无颈淋巴结转移的喉鳞癌细胞相比 ,有颈淋巴结转移喉鳞癌细胞 6 7-KDLN -R的表达水平更高 (P <0 .0 5 )。 结论 6 7-KDLN -R在喉鳞癌分化、增殖、浸润及转移中起重要作用。
Objective To observe the expression of 6 7-KDlaminin receptor (6 7-KDLN-R) in human laryngeal squamous cell carcinoma (LSCC) and to analyze the relationship between its expression and clinicopathological features. Methods Immunohistochemical SP method was used to detect the expression of 6 7-KDLN-R in 30 cases of primary laryngeal squamous cell carcinoma and 3 cases of cervical lymph node metastasis. Results The positive rate of 67-KDLN-R in primary laryngeal squamous cell carcinoma was 56.7% (17/30). The result of the immune response of the metastatic lymph nodes is consistent with the result of the immune reaction of the primary site. The expression of 6 7-KDLN-R was closely related to the degree of tumor differentiation, and the higher expression level of 6 7-KDLN-R was higher (P <0.05). Compared with laryngeal squamous cell carcinoma without lymph node metastasis, the expression of 6 7-KDLN-R in cervical lymph node metastasis laryngeal squamous cell carcinoma was higher (P <0.05). Conclusion 6 7-KDLN-R plays an important role in the differentiation, proliferation, invasion and metastasis of laryngeal squamous cell carcinoma.