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目的 :探讨心理因素与老年癌症患者之间的关系及其抑郁治疗的效果。方法 :对34名老年癌症患者进行汉密尔顿抑郁量表 (HAMD)和症状自评量表 (SCL -90)评分并与34名正常老年人进行比较。给予34名癌症患者服用盐酸氟西汀 (百忧解 )每日20mg治疗8周后 ,再次进行HAMD和SCL -90评分 ,并与治疗前进行比较。同时测定癌症患者抑郁治疗前后外周血中的T细胞亚群及免疫球蛋白。结果 :老年癌症患者与正常老年人比较有明显的心理障碍 ,通过给予抗抑郁治疗后 ,明显改善 ,HAMD和SCL -90评分降低 ,免疫球蛋白G、A、M和T细胞亚群显著增高。结论 :癌症与心理因素密切相关 ,经抗抑郁治疗后 ,患者的心理障碍及免疫状态得到明显改善 ,有助于其它方法对癌症的治疗。
Objectives: To explore the relationship between psychological factors and elderly cancer patients and the effect of depression treatment. Methods: Thirty-four elderly cancer patients were scored for Hamilton Depression Scale (HAMD) and Symptom Checklist (SCL-90) and compared with 34 normal elderly people. Thirty-four cancer patients were treated with fluoxetine hydrochloride (Prozac) for 20 weeks daily for 8 weeks. HAMD and SCL-90 scores were performed again and compared with pretreatment. Simultaneous determination of T cell subsets and immunoglobulins in peripheral blood before and after treatment of depression in cancer patients. RESULTS: Older cancer patients had significant mental disorders compared with normal elderly patients. After the treatment with antidepressants, the scores improved significantly. The scores of HAMD and SCL-90 decreased, and the immunoglobulin G, A, M, and T cell subsets increased significantly. Conclusion: Cancer is closely related to psychological factors. After antidepressant treatment, the patient’s mental disorders and immune status have been significantly improved, which is helpful for other methods of cancer treatment.