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目的探讨中间高血糖(IHG)及其各组份单纯空腹血糖受损(I-IFG,C组)、单纯糖耐量受损(I-IGT,D组)及空腹血糖受损合并糖耐量受损(IFG﹢IGT,E组)的内皮功能损害与遗传和代谢性因子的关系。方法 IHG者共215例,包括C组60例、D组83例和E组72例,与糖耐量正常者(N组)共142例作对照,作口服葡萄糖耐量试验及胰岛素释放试验,检测0min 、10min、20min、30min、60min、120min血糖、免疫活性胰岛素,同时检测空腹血脂、游离脂肪酸(FFA)、脂联素(APN)、超敏C反应蛋白(hs-CRP)、内皮素(SET),留取晨尿测定内皮素(UET)与微量白蛋白(MUA),并观察血压、身高和体重,测定肱动脉休息时、加压及服用硝酸甘油后的内径变化。结果校正年龄和性别后,IHG组、C组、D组、E组的内皮指标hs-CRP、MUA、SET、UET、EDD及EID与N组比较有显著性差异(<0.05或<0.01),D组的hs-CRP、SET和UET与C组比较有显著性差异(<0.05或<0.01),E组的hs-CRP、MUA、SET、UET和EDD分别与C组和D组比较有显著性差异(<0.05或<0.01)；因子分析显示六个因子中其中五个甘油三酯、胰岛素水平、胰岛素抵抗、血糖和血压因子与内皮改变关系密切,其中家族史和肥胖等变量与多个因子密切相关。结论 IHG及其各组分均出现了大血管和微血管内皮功能损害,C组较轻,D组较重,E组最严重；在家族史和肥胖的基础上独立或联合如血脂、葡萄糖、胰岛功能、胰岛素抵抗和血压等代谢因素损害IHG内皮功能。“,”Objective To explore characteristics of risk factors and endothelial dysfunction in intermediate hyperglycemia (group IHG) besides isolated impaired fasting glucose (I-IFG ,group C) , isolated impaired glucose tolerance (I-IGT,group D) and impaired fasting glucose combining impaired glucose tolerance (IFG﹢IGT,group E) .Methods 215 cases of IHG were divided into 60 cases of group C and 83 cases of group D and 72 cases of group E, and compare to142 cases of normal glucose tolerance (group N). Al cases were detected glucose and insulin of 0min,10min,20min,30min, 60min and 120min with oral glucose tolerance test and insulin release test ,and fasting of blood lipids,free fat y acids (FFA),adiponectin (APN)and serum endothelin-1 (SET-1), and urine endothelin-1 (UET-1)and urea-microalbumin (MUA)after col ecting urina sanguinis . To be observed blood pressure,height and weight ,and the arteria brachialis diameter was tested at lest and after arteria brachialis elevated pressure and glycergl trintrate .Results It is significant dif erence between group IHG and group N in hs-CRP,MUA,SET,UET,endothelium-dependent hs-CRP,MUA, SET,UET,endothelium-dependent vasodilatation (EDD), and endothelium-Independent vasodilatation (EID) ,and between group D and group C in hs-CRP,SET and UET ,and between group E and group C/group D in hs-CRP,MUA,SET,UET and EDD after adjusting for sex and age ( <0.05 or <0.01).In factor analysis, triglyceride, level of insulin,insulin resistance, blood glucose and blood pressure in five of six factors are closely related with endothelial dysfunction,and family history and obesity so on are closely related with some factors .Conclusion The endothelial dysfunction in microvessel and greatvessel are founded in group and among of IHG including group E, group D and group C ,the most serious one is group E,more serious one is group D .This finding indicates that metabolic risk factors are independent risk factors or someone are abonder for endothelial dysfunction in IHG such as blood glucose,blood lipid, insulin resistance , insulin secretion function and blood pressure on the basis of obesity and family history of diabetes mel itus.