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药物性肝病是由于药物或其代谢产物导致肝细胞损害,引起的临床综合征。临床多表现为黄疸、转氨酶升高等,可伴发热和皮疹,病程常可逆转,重者可有肝坏死甚至导致死亡。药物的肝内代谢肝脏是药物代谢的重要器官。药物进入人体后,部分药物经肝脏生物转化获得药理活性,其代谢过程分两个阶段。第一阶段称为Ⅰ相反应,通过氧化、还原或水解作用将药物转化成相应产物,此过程由肝脏一组单氧化酶系催化,其中细
Drug-induced liver disease is due to drugs or their metabolites lead to liver cell damage, caused by clinical syndrome. More clinical manifestations of jaundice, elevated transaminases, etc., can be accompanied by fever and rash, the course can often be reversed, severe liver necrosis may even lead to death. Intrahepatic metabolism of drugs Liver is an important organ of drug metabolism. After the drug enters the human body, some drugs are biologically transformed by the liver to obtain pharmacological activity, and the metabolic process is divided into two stages. The first phase is called phase I reaction, and the drug is converted to the corresponding product by oxidation, reduction or hydrolysis, which is catalyzed by a group of monooxygenase enzymes in the liver, where the fine