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自从1935年Domagk氏发现百浪多息对于感染溶血性鏈球菌的小白鼠有很强的治疗作用以后,引起各国科学家的重視,继而大量合成了磺胺、磺胺噻唑、磺胺胍、磺胺嘧啶等,为细菌感染疾病的治疗开辟了新的一頁,在临床工作中起了很大的作用。后来由于抗菌素的出现,磺胺类药物虽有所逊色,但磺胺类药物具有疗效确实、应用方便、价格低廉、毒性較小、过敏反应較少等优点,因此目前仍是一种向疾病作斗争的有力武器。尤其是近年来合成了抗菌譜广、抗菌力强、吸收良好、排泄較
Since 1935, Domagk’s discovery that a hundred waves interest in hemolytic streptococcus infection in mice has a strong therapeutic effect later attracted the attention of scientists from various countries, followed by a large number of synthetic sulfa, sulfathiazole, sulfadiazine, sulfadiazine, etc. The treatment of bacterial infections has opened up a new chapter in clinical work has played a significant role. Later, due to the emergence of antibiotics, sulfonamides, although somewhat inferior, but the sulfa drugs with curative effect, easy to use, low cost, less toxic, less allergic reactions, etc., so it is still a fight against the disease Powerful weapon. In recent years, especially the synthesis of broad spectrum antibacterial, strong antibacterial, good absorption, excretion more