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目的探讨生长激素(growth hormone,GH)对子宫内膜发育不良患者内膜及临床结局的影响。方法回顾分析2007年12月至2010年12月因子宫内膜发育不良致体外受精-胚胎移植(in vitro fertilization-embryotransfer,IVF-ET)治疗失败的67例患者再次IVF时随机分为两组,研究组(32例)加用GH,对照组(35例)不加用GH,观察两组内膜情况及临床结局。结果研究组内膜厚度及形态较对照组明显改善,差异有统计学意义(P<0.05)。研究组取卵数及优胚数略高于对照组,但差异无统计学意义(P>0.05)。研究组妊娠率(37.5%)明显高于对照组(14.3%),差异有统计学意义(P<0.05)。结论 GH可改善内膜发育不良患者的内膜厚度及形态,提高内膜容受性,从而提高IVF妊娠率。
Objective To investigate the effect of growth hormone (GH) on endometrial and clinical outcomes in patients with endometrial dysplasia. Methods Retrospective analysis of 67 patients with failure of in vitro fertilization-embryotransfer (IVF-ET) treatment from December 2007 to December 2010 were randomly divided into two groups after IVF, The study group (32 cases) plus GH, the control group (35 cases) without GH, the endometrial conditions and clinical outcomes were observed. Results The intima thickness and morphology of the study group were significantly improved compared with the control group, the difference was statistically significant (P <0.05). The number of oocytes and the number of excellent embryos in the study group was slightly higher than that in the control group, but the difference was not statistically significant (P> 0.05). The pregnancy rate (37.5%) in study group was significantly higher than that in control group (14.3%), the difference was statistically significant (P <0.05). Conclusions GH can improve intima thickness and morphology in patients with dysplasia of the intima, improve endometrial receptivity, and improve IVF pregnancy rate.