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高三尖杉酯碱(HHT)是一种对骨髓有显著抑制作用和毒性小的植物生物碱。HHT都用于急粒白血病治疗,但对慢粒白血病(CML)的治疗作用研究较少。作者研究HHT对晚期慢性期CML的治疗作用。 病人和方法 71例CML晚期慢性期病人。其中活动期58例,缓解期13例(从诊断到治疗的时间超过12个月),全部Ph染色体阳性,其中58例曾接受IFN-α治疗,41例对IFN-α耐药。HHT通过中心静脉导管持续输注,剂量2.5mg/m~2·d.连用14天,血液学缓解后维持治疗每月用7天。使用天数则根据粒细胞达最低
Homoharringtonine (HHT) is a plant alkaloid that has a significant inhibitory effect on the bone marrow and is less toxic. HHT is used for the treatment of acute leukemia, but there are few studies on the therapeutic effects of chronic myeloid leukemia (CML). The authors studied the therapeutic effect of HHT on advanced chronic CML. Patients and Methods 71 cases of CML patients with advanced chronic disease. Of these, 58 cases were in active phase and 13 in remission phase (from diagnosis to treatment lasting more than 12 months). All Ph chromosomes were positive, of which 58 cases received IFN-alpha therapy and 41 cases were resistant to IFN-alpha. HHT was continuously infused through a central venous catheter with a dose of 2.5 mg/m~2 d for 14 days. Hematologic remission was followed by maintenance therapy for 7 days per month. The number of days used is based on the lowest number of granulocytes