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目的探讨甲亢患者突眼症状与遗传、环境因素的关系。方法对甲亢突眼病例组、无突眼病例组和对照组（每组３０名女性）的淋巴细胞微核进行检测。结果各组的微核率依次为４．２３±２．２５％、２．０５±１．５％和０．９７±０．７４％。甲亢突眼组的微核率与无突眼组相比较有显著差异（Ｐ＜０．０１），同时，两组的微核率明显高于对照组（Ｐ＜０．０１）。结论甲亢患者有疾病易感倾向，而且，患者的病情与微核率均表现出多因素的累加效应。
Objective To investigate the relationship between exophthalmos symptoms and genetic and environmental factors in patients with hyperthyroidism. Methods Lymphocyte micronuclei were detected in cases of hyperthyroidism exophthalmos, cases without exophthalmos and controls (30 women in each group). Results The rates of micronuclei in each group were 4.23 ± 2.25%, 2.05 ± 1.5% and 0.97 ± 0.74%, respectively. The micronucleus rate in hyperthyroidism group was significantly higher than that in non-exophthalmos group (P <0.01). Meanwhile, the micronucleus rate in the two groups was significantly higher than that in the control group (P <0.01). Conclusions Patients with hyperthyroidism have a tendency to be susceptible to the disease. Moreover, the patient’s condition and micronucleus rate all show cumulative effects of multiple factors.