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作者应用扫描电镜和透射电镜,观察了吡喹酮(消旋吡喹酮,译者注)、左旋吡喹酮和右旋吡喹酮对日本血吸虫和曼氏血吸虫雌雄虫的皮层及生殖器官超微结构的损害。取5周龄的雄性ICR小鼠,每鼠经皮肤感染30条日本株的日本血吸虫尾蚴,或通过浸尾法每鼠感染100条波多黎各株曼氏血吸虫尾蚴。动物于感染后35天,分别一次口服左旋吡喹酮、右旋吡喹酮或吡喹酮,剂量为500mg/kg,并于服药后1、3和7天处死,从
Using scanning electron microscopy and transmission electron microscopy, the effects of praziquantel (praziquantel), prazosin and praziquantel on the cortical and reproductive organs of Schistosoma japonicum and S. mansoni Microstructural damage. Five-week-old male ICR mice were inoculated per mouse with 30 Japanese strains of Schistosoma japonicum cercariae percutaneously or infected with 100 strains of S. mansoni cercariae per litter by tail-immersion. Animals were orally given either prazosin, praziquantel or praziquantel at a dose of 500 mg / kg orally 35 days after infection and sacrificed on days 1, 3 and 7 after dosing, starting from