An Efficient Synthesis of Cyclopeptides Bridged with Aliphafic-aryl Ether Bond

• 作 者: Zhe LIU Gui Jei TIAN De Xin WA
• 机 构: Institute of Materia Medica
• 出 处: 中国化学快报（英文版）
• 发表日期: 2004年期
• 关键词: Intramolecular SN2 reaction cyclopeptide solid-phase organic synthesis pseudo-di

Based on the pseudo-dilution effect (PDE) on solid support, three cyclopeptides with an aliphatic-aryl ether bond as the bridge were synthesized via SN2 reaction between bromoacetylated at N-terminal and the phenol -OH group in C-terminal Tyr residue. All the products were obtained in good overall yields and characterized by related analytic data.