论文部分内容阅读
目的探讨三维适形放疗(3DCRT)同步联合紫杉醇(TAX)+顺铂(DDP)之TP化疗方案治疗局部晚期非小细胞癌(NSCLC)的近期疗效。方法选取2010年1月至2012年5月间收治的局部晚期NSCLC患者88例,随机分为A组(46例)和B组(42例),B组患者采用3DCRT放疗治疗,A组患者在此基础上加TP化疗方案,观察并记录两组患者的近期疗效和药物不良反应。结果 A组患者完全缓解率为13.0%,总有效率为82.6%,KPS评分为(79.5±8.2)分,均高于B组患者的4.8%、64.3%和(75.7±7.8)分,两组患者总有效率和KPS评分差异有统计学意义(P<0.05)。A组患者骨髓抑制、放射性肺损伤和末梢神经损害发生率高于B组(P<0.05);同步放化疗期间病死率(4.3%,2/46)高于B组(2.4%,1/42),但差异无统计学意义(P>0.05)。结论 3DCRT放疗同步联合TP化疗方案能有效控制NSCLC原发病灶进展,提高患者生活质量,积极处理同步放化疗期间的不良反应尤为重要。
Objective To investigate the short-term curative effect of three-dimensional conformal radiotherapy (3DCRT) combined with paclitaxel (TAX) + cisplatin (DDP) TP chemotherapy on locally advanced non-small cell lung cancer (NSCLC). Methods Eighty-eight patients with locally advanced NSCLC who were admitted between January 2010 and May 2012 were randomly divided into group A (n = 46) and group B (n = 42). Patients in group B received 3DCRT radiotherapy. Patients in group A On the basis of adding TP chemotherapy, observe and record the short-term efficacy of the two groups of patients and adverse drug reactions. Results In group A, the complete remission rate was 13.0%, the total effective rate was 82.6% and the KPS score was 79.5 ± 8.2, which were all higher than those in group B (4.8%, 64.3% and 75.7 ± 7.8) The total effective rate and KPS score difference was statistically significant (P <0.05). The incidence of bone marrow suppression, radiation-induced lung injury and peripheral nerve injury in group A was higher than that in group B (P <0.05). The mortality rate in group A was higher than that in group B (2.4%, 1/42) during concurrent chemoradiotherapy (4.3%, 2/46) , But the difference was not statistically significant (P> 0.05). Conclusions 3DCRT radiotherapy combined with TP chemotherapy regimen can effectively control the progression of primary NSCLC lesions and improve the quality of life of patients. Active treatment of adverse reactions during concurrent chemoradiotherapy is particularly important.