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目的:研究中药蝙蝠葛的化学成分。方法:应用硅胶和凝胶反复柱层析进行分离,分得成分用波谱分析和理化性质对照进行结构鉴定。结果:分离鉴定出11种成分,分别为dauricumine(1),dauricumidine(2),acutuminine(3),physcion(4),blumenolC(5),blumenolA(6),N-transferuloyltyramine(7),vanillin(8),β-sitostenone(9),β-sitosterol(10),和daucosterol(11)。结论:含氯生物碱1和2为首次从天然来源中分得,含氯生物碱3的NMR数据和立体结构为首次报道,化合物4-11均为首次从本植物中分到。
Objective: To study the chemical composition of Chinese medicine Dabu Ge. Methods: Silica gel and gel repeated column chromatography were used for separation. The components were identified by spectral analysis and physical and chemical properties. RESULTS: Eleven components were isolated and identified as dauricumine (1), dauricumidine (2), acutuminine (3), physcion (4), blumenol C (5), blumenol A (6), N-transferuloyltyramine 8), β-sitostenone (9), β-sitosterol (10), and daucosterol (11). CONCLUSION: The first and second chlorine-containing alkaloids were separated from natural sources. The NMR data and the three-dimensional structure of chlorine-containing alkaloids 3 were reported for the first time. Compounds 4-11 were first isolated from this plant.