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目的:研究有机磷农药中毒致肝脏损伤后胆汁引流与疏肝利胆中药对肝脏的保护作用。方法:制作有机磷农药中毒的动物模型后,分成传统治疗组和中西医结合治疗组,对后者行胆囊造瘘胆汁引流加疏肝利胆中药相结合治疗,观察2组动物肝脏组织病理变化及酶学改变并与正常对照组比较。结果:犬有机磷农药中毒后肝脏损伤确实,胆汁引流与疏肝利胆中药结合治疗后肝脏形态结构及功能状态明显优于传统治疗组。结论:胆汁引流与疏肝利胆中药对肝脏有保护作用,为抢救有机磷农药中毒提出了一个新的治疗理论
Objective: To study the protective effect of bile drainage and Shugan gallbladder medicine on liver after liver injury caused by organophosphorus pesticide poisoning. Methods: Animal models of organophosphorus pesticide poisoning were divided into traditional treatment group and traditional Chinese medicine combined with western medicine treatment group. The latter was treated with gallbladder ostomy with bile drainage combined with Chinese herb of liver and gallbladder. The pathological changes of liver tissues in two groups were observed And enzymatic changes and compared with the normal control group. Results: The organ damage caused by organophosphorus pesticide poisoning in dogs was confirmed. The morphological structure and functional status of liver after bile drainage combined with Chinese herb of Shugan and gallbladder were significantly better than that of the traditional treatment group. Conclusion: Bile drainage and Shugan gallbladder medicine have protective effect on the liver, and a new treatment theory for salvage of organophosphorus pesticide poisoning