论文部分内容阅读
目的:探讨老年骨质疏松患者血清白介素-2(IL-2)、肿瘤坏死因子α(TNF-α)、胰岛素样生长因子(IGF-1)水平的变化及其临床意义。方法:选择2004-06/2009-06我院门诊或住院诊治老年患者158例,根据骨质疏松诊断标准分为骨质疏松组(52例)和骨量减少组(106例),另选择同期老年体检者50例为对照组。对各组进行血清IL-2、TNF-α、IGF-1检测及腰椎和股骨颈骨密度测定。结果:老年骨质疏松组及骨量减少组血清IL-2和IGF-1水平均明显低于老年正常和对照组(P<0.05),血清TNF-α水平明显高于老年正常对照组(P<0.05);老年骨量减少与骨质疏松组腰椎及股骨颈的骨密度均明显低于老年正常对照组(P<0.05),同时老年骨质疏松组骨密度也明显低于骨量减少组(P<0.05);血清中IL-2和IGF-1水平与老年人群腰椎、股骨的骨密度值均呈正相关(r=0.35,0.39,P<0.05),而TNF-α与老年人群腰椎、股骨的骨密度值呈负相关(r=-0.35,P<0.05)。结论:IL-2、TNF-α及IGF-1对辅助诊断和治疗老年骨质疏松症有一定价值。
Objective: To investigate the changes of serum levels of interleukin-2, tumor necrosis factor-alpha (TNF-α) and insulin-like growth factor (IGF-1) in elderly patients with osteoporosis and its clinical significance. Methods: One hundred and eighty-five elderly patients diagnosed and treated in our hospital from June 2004 to June 2009 were divided into osteoporosis group (n = 52) and osteopenia group (n = 106) based on the diagnostic criteria of osteoporosis. Elderly physical examination in 50 cases as a control group. The levels of IL-2, TNF-α and IGF-1 in serum were measured in each group, and the BMD of lumbar and femoral neck were measured. Results: The levels of serum IL-2 and IGF-1 in elderly osteoporosis group and osteopenia group were significantly lower than those in the elderly and control group (P <0.05), and the levels of serum TNF-α were significantly higher than those in the elderly control group (P <0.05). The bone mineral density of lumbar spine and femoral neck in aged group with osteopenia and osteoporosis were significantly lower than those in normal control group (P <0.05), meanwhile the BMD in senile osteoporosis group was significantly lower than that in osteopenia group (P <0.05). The levels of IL-2 and IGF-1 in serum were positively correlated with the BMD of the lumbar and femur in the elderly (r = 0.35,0.39, P <0.05) Femoral bone mineral density was negatively correlated (r = -0.35, P <0.05). Conclusion: IL-2, TNF-α and IGF-1 have some value in the diagnosis and treatment of senile osteoporosis.