论文部分内容阅读
选择子宫腺肌病住院手术病人４５例，采用ＡＢＣ免疫组化法测定石蜡固定包埋的深肌层异位内膜标本中雌二醇（Ｅ２）、孕激素（Ｐ）、睾酮（Ｔ）、雌激素受体（ＥＲ）、孕激素受体（ＰＲ）、雄激素受体（ＡＲ）。另取１７份增生期原位内膜作对照，分析性激素及性激素受体与临床表现的关系。研究发现子宫深肌层异位内膜有Ｅ２、Ｐ、Ｔ、ＥＲ、ＰＲ、ＡＲ阳性细胞存在，其中ＥＲ、ＡＲ阳性表达率显著高于原位内膜。但性激素及性激素受体的阳性率与子宫腺肌病的临床症状、病程和子宫体积无明显关系。提示：子宫腺肌病的发生、发展除了与雌激素有关外，还与孕激素、雄激素有关，同时应用抑制多种受体的药物可能是治疗子宫腺肌病的途径之一。
Forty - five inpatients with adenomyosis were enrolled in this study. Estradiol (E2), progesterone (P) and testosterone (T) were detected by ABC immunohistochemistry in paraffin - embedded deep myometrium. Estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR). Another 17 cases of proliferative endometrium as control, analysis of sex hormones and sex hormone receptors and clinical manifestations. The study found that there were E2, P, T, ER, PR and AR positive cells in the ectopic endometrium of the deep uterus. The positive expression rate of ER and AR was significantly higher than that of in situ endometrium. However, the positive rate of sex hormone and sex hormone receptor and adenomyosis clinical symptoms, duration and no significant relationship between uterine volume. Tip: The occurrence and development of adenomyosis in addition to estrogen, but also with progesterone and androgen, while the application of drugs that inhibit a variety of receptors may be one of the ways to treat adenomyosis.