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儿童急性淋巴细胞白血病的疗效,应从停止所有治疗后持续完全缓解病例比例作最后评价。作者总结了他们从1962年12月底到1975年10月,经过8个方案治疗的639例儿童急性淋巴细胞白血病,随访观察到1978年8月1日。停止治疗的标准:(1)首次完全缓解持续2(1/2)年;(2)血液学缓解至少维持2(1/2)年,髓外部位(中枢神经系统或睾丸)复发治疗成功后最少一年或(3)一次或多次血液学复发后又获得第二次完全缓解符合以上二项标准。1967年以后诱导缓解用强地松、长春新碱,有时联用正定霉素或L-门冬酰胺酶(或两者)。完全缓解病例早期接受预防性颅内
The efficacy of childhood acute lymphoblastic leukemia should be discontinued after all the treatment of patients with complete remission cases for the final evaluation of the proportion of patients. The authors summarized 639 children with acute lymphoblastic leukemia who were treated with eight regimens from the end of December 1962 until October 1975 and were followed up on August 1, 1978. The criteria for discontinuation of treatment were: (1) complete first complete remission for 2 (1/2) years; (2) hematological remission for at least 2 (1/2) years; successful extramedullary (central nervous system or testicular) relapse A minimum of one year or (3) a second complete remission after one or more hematological remissions in line with the above two criteria. Prednisolone and vincristine for induction of remission after 1967, sometimes combined with n-amidin or L-asparaginase (or both). Complete remission of early acceptance of prophylactic intracranial