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目的:探讨CA125对肺癌鉴别诊断和观察疗效的临床意义。方法:采用免疫放射分析法测定健康人和按组织学分类的各类肺癌患者血清CA125水平及阳性率,同时检测各样品的血清CEA水平,进行统计分析。结果:患者组较健康对照组CA125水平显著增高(P<0.01)。肺鳞癌组CA125阳性率为84％,腺癌为65％,腺鳞癌为56％,小细胞肺癌为40％;1例大细胞肺癌CA125检测值为230U/ml、CEA值为18ng/mL。肺鳞癌阳性率较其它组x~2检验有显著意义(p<0.01),CA125与CEA呈正相关(R=0.852)。结论:血清CA125可作为对肺癌早期诊断、鉴别诊断及观察疗效的较好参考指标。
Objective: To investigate the clinical significance of CA125 in the differential diagnosis and observation of lung cancer. Methods: Serum CA125 level and positive rate of healthy lung cancer patients and all kinds of lung cancer patients by immunohistochemical method were determined. Serum CEA level of each sample was also measured and statistically analyzed. Results: The level of CA125 in patients was significantly higher than that in healthy controls (P <0.01). The positive rate of CA125 was 84% in lung squamous cell carcinoma, 65% in adenocarcinoma, 56% in adenosquamous carcinoma and 40% in small cell lung cancer. The detection value of CA125 in 1 large cell lung cancer was 230 U / ml and CEA was 18 ng / mL . The positive rate of squamous cell carcinoma was significantly higher than that of other groups (p <0.01). There was a positive correlation between CA125 and CEA (r = 0.852). Conclusion: Serum CA125 can be used as a good reference for early diagnosis, differential diagnosis and observation of lung cancer.