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对１４６例慢性乙型肝炎、肝硬化和肝细胞癌标本作了免疫组化染色，观察其ｃ－ｅｒｂＢ－２癌基因蛋白（Ｐ１８５）及增殖细胞核抗原（ＰＣＮＡ）的表达情况，探讨他们在ＨＢＶ诱发ＨＣＣ过程中的作用和意义。结果：（１）在ＨＢＶ感染的慢性肝炎阶段已出现ｃ－ｅｒｂＢ－２Ｐ１８５和ＰＣＮＡ的异常表达，总阳性率分别为８７％和８．１％；（２）由慢性乙肝、肝硬化向肝细胞癌发展过程中，出现了ＰＣＮＡ表达逐渐升高，ｃ－ｅｒｂＢ－２Ｐ１８５逐渐下降的趋势：（３）证实了ｃ－ｅｒｂＢ－２１８５与肝病理炎症程度密切相关，而ＰＣＮＡ主要反映细胞增殖状态。由此可见，ＨＢＶ致ＨＣＣ过程是一个早以炎症为主，逐渐过度为细胞增殖为主的多阶段复杂过程。
146 cases of chronic hepatitis B, cirrhosis and hepatocellular carcinoma specimens were immunohistochemically stained to observe the expression of c-erbB-2 oncogene protein (P185) and proliferating cell nuclear antigen (PCNA) The role and significance of HCC induction. Results: (1) Abnormal expression of c-erbB-2P185 and PCNA had been found in chronic hepatitis with HBV infection, with the total positive rates of 87% and 8.1% respectively; (2) From chronic hepatitis B and cirrhosis to hepatocytes During the process of cancer development, the expression of PCNA gradually increased and the c-erbB-2P185 gradually decreased. (3) It was confirmed that c-erbB-2185 was closely related to the degree of liver pathological inflammation, while PCNA mainly reflected the state of cell proliferation. Thus, HBV-induced HCC process is an early inflammatory mainly gradual excessive cell proliferation-based multi-stage complex process.