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目的探讨胰岛素泵治疗妊娠糖尿病的有效性及安全性。方法 42例妊娠糖尿病患者随机分为观察组20例,对照组22例。观察组接受胰岛素泵治疗,对照组接受多次皮下胰岛素治疗。分别比较两组于治疗前及治疗后2周,空腹血糖、餐后2 h血糖、低血糖事件发生次数、血糖达标时间、胰岛素日均用量。比较两组于治疗后8周糖化血红蛋白水平及8周治疗中遗忘注射胰岛素次数。结果治疗2周后两组餐后2 h血糖水平比较(P<0.05);两组血糖达标时间、低血糖发生率、遗忘注射胰岛素次数比较(P<0.05)。结论在控制妊娠糖尿病患者餐后血糖,降低低血糖风险,减少胰岛素日均用量,缩短血糖达标时间及提高患者依从性方面较多次皮下注射胰岛素更具优势。
Objective To investigate the efficacy and safety of insulin pump in the treatment of gestational diabetes mellitus. Methods Forty-two gestational diabetes patients were randomly divided into observation group (20 cases) and control group (22 cases). The observation group received insulin pump treatment, the control group received multiple subcutaneous insulin therapy. The levels of fasting blood glucose, 2-hour postprandial blood glucose, incidence of hypoglycaemia, glycemic control time and daily insulin dosage were compared between the two groups before treatment and 2 weeks after treatment. The levels of HbA1c at 8 weeks after treatment and the number of forgotten injections during 8 weeks of treatment were compared between the two groups. Results After 2 weeks of treatment, the blood glucose levels of the two groups at 2 hours after meal were compared (P <0.05). The blood glucose level, the incidence of hypoglycemia and the number of insulin injections were compared between the two groups (P <0.05). Conclusions More subcutaneous insulin injections is more advantageous in controlling gestational diabetes mellitus after meals, lowering the risk of hypoglycaemia, decreasing the average daily dosage of insulin, shortening the blood glucose compliance time and improving patient compliance.