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应用 ELSA 法检测了105例甲、乙型肝炎患者和20例健康献血员血清肿瘤坏死因子(TNF)含量,结果显示:乙肝慢性迁延型、急性、急性重症、甲型肝炎,乙肝慢性活动型,慢性重症组血清 TNF 水平依次升高,与对照组比较均有显著性差异(P<0.01),甲型肝炎组血清 TNF 含量仅次于慢活肝组(P>0.05)和慢重肝组(P<0.05)。慢活肝与慢重肝组无论并发原发性腹膜炎与否仍以慢重肝组血清 TNF 含量居高。提示肝炎患者血清 TNF 含量与病情,不同类型病毒感染及内毒素关系密切。
The serum levels of tumor necrosis factor (TNF) in 105 cases of hepatitis A and B and 20 cases of healthy blood donors were detected by ELSA. The results showed that: Chronic persistent hepatitis B, acute, severe acute, Hepatitis A, Chronic active hepatitis B, Serum levels of TNF in patients with chronic severe disease increased successively, compared with those in the control group (P <0.01). The levels of serum TNF in the patients with hepatitis A were only less than those in the chronic active hepatitis group (P> 0.05) and chronic severe hepatitis group P <0.05). Slow active liver and chronic severe hepatitis group regardless of complicated with primary peritonitis or not still heavy liver serum TNF levels remain high. It is suggested that the level of serum TNF in patients with hepatitis is closely related to the disease, different types of virus infection and endotoxin.