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目的探讨半夏泻心汤防治结直肠癌化疗患者胃肠道反应的效果。方法选择2011年6月—2013年6月收治的结直肠癌术后化疗患者60例,随机分为对照组与治疗组各30例,对照组化疗日加常规止吐药物胃复安10 mg/次肌内注射,2次/d。治疗组在对照组基础上化疗前3 d予半夏泻心汤口服。化疗结束后12 h对比两组恶心呕吐、腹泻情况。计数资料采用χ2检验,P<0.05为差异有统计学意义。结果化疗后恶心呕吐有效率对照组70.0%,治疗组90.3%,两组比较差异有统计学意义(P<0.05)。化疗后腹泻有效率两组比较差异无统计学意义(P>0.05)。结论半夏泻心汤可以有效预防结直肠癌化疗患者胃肠道反应,且方法简便,费用低廉,值得临床推广。
Objective To investigate the effect of Banxiaxiexin Decoction in preventing and treating gastrointestinal reactions in patients undergoing chemotherapy for colorectal cancer. Methods Sixty patients with postoperative chemotherapy for colorectal cancer who were admitted to our hospital from June 2011 to June 2013 were randomly divided into control group and treatment group, 30 cases each. The control group received conventional chemotherapy and metoprolol 10 mg / Times intramuscular injection, 2 times / d. The treatment group was given oral administration of Banxiaxiexin Decoction 3 days before chemotherapy on the basis of the control group. 12 h after chemotherapy compared two groups of nausea and vomiting, diarrhea. Count data using χ2 test, P <0.05 for the difference was statistically significant. Results After chemotherapy, the effective rate of nausea and vomiting was 70.0% in the control group and 90.3% in the treatment group, with significant difference between the two groups (P <0.05). The effective rate of diarrhea after chemotherapy was no significant difference between the two groups (P> 0.05). Conclusion Banxiaxiexin Decoction can effectively prevent gastrointestinal reactions in patients with chemotherapy of colorectal cancer, and the method is simple, inexpensive and worthy of clinical promotion.