论文部分内容阅读
炎症包括一系列病理生理活动,且因人而异,有急性或慢性,有器官特异的如哮喘,有可逆或不可逆的.但有一点可以肯定,即有多种介质参与:有胺类如组胺和5-HT;短肽如缓激肽,长肽如白细胞介素-1(IL-1);还有类脂如前列腺素(PG)和白三烯,以及游走细胞释放的酶和补体等.通过用酶抑制剂防止介质产生,或用选择性拮抗剂阻断介质的药理作用就可确定每一介质的重要性.
Inflammation involves a range of pathophysiological activities that vary from person to person and are acute or chronic, organ-specific, such as asthma, reversible or irreversible, but one thing is certain: there are many mediators involved: Amines and 5-HT; short peptides such as bradykinin, long peptides such as interleukin-1 (IL-1); and also lipids such as prostaglandins (PGs) and leukotrienes, Complement, etc. The importance of each medium can be determined by preventing the production of the medium with an enzyme inhibitor or by blocking the pharmacological effects of the medium with a selective antagonist.