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糖胺聚糖(glycosaminoglycan,GAG)是一类含有糖醛酸和氨基糖残基的重要生物大分子。在细胞表面和细胞外基质中存在着一些高亲和力的GAG结合细胞因子,如血管内皮生长因子(vascular endothelial growth factor,VEGF)、中期因子(midkine,MK)、骨桥蛋白(osteopontin,OPN)、肝素酶(heparanase,HPA)、碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)。它们除了具有多种生物学作用外,还与肿瘤发生、发展有着密切联系。GAG结合细胞因子在肿瘤分子诊断、靶向治疗方面的研究和应用已越来越受关注。
Glycosaminoglycan (GAG) is a class of important biological macromolecules containing uronic acid and amino sugar residues. There are some high-affinity GAG-binding cytokines in cell surface and extracellular matrix, such as vascular endothelial growth factor (VEGF), midkine (MK), osteopontin (OPN) Heparanase (HPA), basic fibroblast growth factor (bFGF). In addition to their diverse biological roles, they are closely linked to tumorigenesis and development. GAG combined with cytokines in tumor molecular diagnosis, targeted therapy research and application has been more and more attention.