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Graves病的本质 1974年讨论时,在Graves病发现了很多自身免疫现象,以致不得不用自身免疫来解释这个疾病。是否自身免疫不正常是真正引起甲状腺功能亢进(简称甲亢)和该病自主的特点,如果是的话,是否通过体液或者中介细胞(Cell-Mediated)机制,到1977年这个问题已搞清楚。现在可以说Graves病的甲亢可能是直接由于特殊的自身免疫抗体或者被称为刺激甲状腺免疫球蛋白(TSI)的一族抗体引起的。 TSI是一个甲状腺滤泡细胞受体或是其成份的抗体。因此,Graves甲亢似乎是抗受体抗体的自身免疫性疾病中新亚族的一种疾病。作者举出三种这样的疾病:一种特殊类型的抗
The Nature of Graves Disease In the 1974 discussion, many autoimmune phenomena were discovered in Graves’ disease, which led to the need to explain the disease with autoimmunity. Whether autoimmune abnormalities really cause hyperthyroidism (Hyperthyroidism) and autonomic characteristics of the disease, and if so, by 1977, the problem of whether to pass the body fluid or cell-mediated mechanism was clarified. It can now be said that hyperthyroidism in Graves’ disease may be caused directly by a specific autoimmune antibody or a family of antibodies known as thyroid immunoglobulin (TSI). TSI is a thyroid follicular cell receptor or antibody to its components. Therefore, Graves hyperthyroidism appears to be a new subfamily of autoimmune diseases that are resistant to receptor antibodies. The author cites three such diseases: a special type of anti-cancer