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[目的]比较microRNA-212(miR-212)在胃癌组织和正常胃黏膜组织中的表达情况,并探讨其与临床病理特征之间的关系。[方法]应用茎环RT-qPCR方法检测22例胃癌及癌旁正常胃黏膜组织标本中miR-212的表达。[结果]miR-212在胃癌及正常胃黏膜组织中的相对表达量分别为1.439和1.000,两者差异有统计学意义(P<0.05)。而且,胃癌组织中miR-212的表达与肿块位置、分化程度、淋巴结转移以及TNM分期有关(P<0.05)。[结论]miR-212的表达可能在胃癌发生发展过程中发挥重要作用。
[Objective] To compare the expression of microRNA-212 (miR-212) in gastric cancer and normal gastric mucosa and to explore its relationship with clinicopathological features. [Method] The stem-loop RT-qPCR method was used to detect the expression of miR-212 in 22 cases of gastric cancer and adjacent normal gastric mucosa. [Results] The relative expression levels of miR-212 in gastric cancer and normal gastric mucosa were 1.439 and 1.000, respectively, with significant difference (P <0.05). Moreover, the expression of miR-212 in gastric cancer tissues was correlated with tumor location, degree of differentiation, lymph node metastasis and TNM stage (P <0.05). [Conclusion] The expression of miR-212 may play an important role in the development of gastric cancer.