论文部分内容阅读
神经病理性疼痛(NP)是由神经系统原发性损害和功能障碍所激发或引起的疼痛,它属于一种慢性疼痛,表现为自发性疼痛、痛觉过敏、异常疼痛和感觉异常等临床特征.由于发病机制尚不明确,其治疗效果不尽人意.神经损伤后,在损伤的部位、背根神经节(DRG)的胶质细胞,释放多种炎症介质参与调节伤害性信息的传递.神经病理性疼痛的炎症过程可能通过某个(些)信号转导通路完成.本文就当前炎症与神经病理性疼痛关系的研究做一综述.“,”Neuropathic pain (NP) is pain triggered or caused by primary damage and dysfunction of the nervous system.It belongs to a kind of chronic pain,which is manifested as spontaneous pain,hyperalgesia,abnormal pain,paresthesia and other clinical characteristics.Because the pathogenesis is not clear,the therapeutic effect is not satisfactory.After nerve injury,the glial cells in the injured site and dorsal root ganglia (DRG) release various inflammatory mediators to participate in the regulation of the transmission of damaging information.The inflammatory process of neuropathic pain may be accomplished through some signaling pathways.This article reviews the current research on the relationship between inflammation and neuropathic pain.