Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restorat

• 作 者: Feng-Zhi Xin Ze-Hua Zhao Rui-N
• 机 构: CenterforFattyLiver,ShanghaiKeyLabofPediatricGastroenterologyandNutrition,ShanghaiInstituteforPediat
• 出 处: 世界胃肠病学杂志:英文版
• 发表日期: 2020年18期
• 关键词: Nonalcoholic fatty liver disease Folic acid Gut microbiota PPARΑ SIRT1
• 基金项目: Supported by National Key R&D Program of China,No.2017YFC0908903,National Natural Science Foundation of China,No.81873565,No.81470840,and No.81700503.

BACKGROUND Folic acid has been shown to improve non-alcoholic steatohepatitis(NASH),but its roles in hepatic lipid metabolism,hepatic one-carbon metabolism,and gut microbiota are still unknown.AIM To demonstrate the role of folic acid in lipid metabolism