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本文报道了维A酸、维E及维C联合应用对预防BaP诱发大鼠肺癌的效果。结果表明,预防组雄鼠的肺癌发生率明显低于阳性对照组(分别为6.2％及38.9％,P=0.019)。 实验中的有趣发现是预防组大鼠大都出现了食道上皮乳头状瘤样增生,发生率雄鼠为68.7％,雌鼠为91.3％,其他各组皆无此现象。作者认为,这是由于在气管注射过程中残留在口腔中的BaP被吞咽时对食道上皮发生了引瘤作用,以后在饲料及饮水中的预防药物的长期促进下最终导致了乳头状瘤的形成。
This article reports the effect of combination of tretinoin, vitamin E and vitamin C on the prevention of BaP-induced lung cancer in rats. The results showed that the incidence of lung cancer in the prevention group was significantly lower than that in the positive control group (6.2% vs 38.9%, respectively; P = 0.019). Interestingly, in the experiment, most of the rats in the prevention group developed esophageal papilloma-like hyperplasia. The incidence of male and female rats was 68.7% and 91.3%, respectively. The authors argue that this is due to the tumorigenic effect of BaP remaining in the oral cavity during tracheal instillation on the esophageal epithelium, which eventually leads to the formation of papilloma after long-term promotion of prophylactic drugs in feed and drinking water .