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本文应用快速检测ＨＢＶＰｒｅ－Ｃ基因突变方法对１１２例乙肝病人及无症状ＨＢＶ携带者（男６１例，女５１例）进行了研究。结果显示９３例ＨＢＶＤＮＡ阳性患者中有１３例有突变感染或与野生株合并感染（１４．０％），总的突变率偏低。突变感染率中，女性高于男性（Ｐ＜０．０５）。年龄较大者突变检出率有增高趋势。突变率与血清丙氨酸转氨酶（ＡＬＴ）水平无关。乙肝病人及ＨＢＶ携带者的突变检出率分别是１８．５％（５／２７）及１２．１％（８／６６）。
In this study, rapid detection of HBV Pre-C gene mutation 112 cases of hepatitis B patients and asymptomatic HBV carriers (61 males and 51 females) were studied. The results showed that 93 out of 93 HBVDNA positive patients had a mutation infection or infection with the wild strain (14.0%), the overall mutation rate was low. Among the mutation infection rates, women were higher than men (P <0.05). Older mutation detection rate has increased trend. Mutation rate and serum alanine aminotransferase (ALT) level has nothing to do. The mutation detection rates of hepatitis B patients and HBV carriers were 18.5% (5/27) and 12.1% (8/66) respectively.