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AIM:To detect the expression pattern of FAK(focaladhesion kinase)and integrin a5 and β1 subunits indifferent kinds of cancerous tissues and to study theircorrelation with clinicopathological data includingtumor type,grade and lymph node status.METHODS:Using an immunohistochemical technique,weexamined the expression of FAK and integrin andsubunits in cancerous and noncancerous tissuesobtained from 75 patients with gastric carcinomas,21colorectal carcinomas,16 hepatocellular carcinomas,20 uterocervical carcinomas,and 20 breast carcinomas.RESULTS:The staining of FAK was stronger in cancerousthan in noncancerous areas.Enhanced expression ofFAKwas detected in poor-differentiated carcinoma ofthe stomach and colorectum.Tumors with lymph nodemetastases had more FAK protein than those withoutmetastases.In addition,the deeper the extent of tumorinfiltration,the higher the FAK expression.Theexpression of integrin α5 and β1 subunits was lower incancerous areas than in noncancerous areas,but it washigher in well-differentiated cancerous tissues than inpoor differentiated tissues.The relationship betweenthe expression of integrin α5 and β1 subunits andinfiltration or metastasis was not significant.Canceroustissues with stronger FAK expression(++or+++)alsohad a higher expression of integrin or5 and β1 subunitsin the tumor and its unaffected margins.CONCLUSION:FAK is a better marker for carcinogenesisand the progression of cancer than integrin or5 or β1subunit,and it may be not only a transformation-linkedenzyme but also a progression-linked enzyme.
AIM: To detect the expression pattern of FAK (focaladhesion kinase) and integrin a5 and β1 subunits indifferent kinds of cancerous tissues and to study their coronallation with clinicopathological data including tumor type, grade and lymph node status. METHODS: Using an immunohistochemical technique, weexamined the expression of FAK and integrin and subunits in cancerous and noncancerous tissuesobtained from 75 patients with gastric carcinomas, 21 colorectal carcinomas, 16 hepatocellular carcinomas, 20 uterocervical carcinomas, and 20 breast carcinomas. RESULTS: The staining of FAK was stronger in cancerous staging in noncancerous areas. Enhanced expression of FAKwas detected in poor-differentiated carcinoma of the stomach and colorectum.Tumors with lymph nodemetastases had more FAK protein than those without metastases. In addition, the deeper the extent of tumor invasion, the higher the FAK expression. Theexpression of integrin α5 and β1 subunits was lower incancerous areas than in noncancerous areas, but it washigher in well-differentiated cancerous tissues than inpoor differentiated tissues. The relationship betweenthe expression of integrin α5 and β1 subunits and in filtration or metastasis was not significant. Cancerroustissues with stronger FAK expression (++ or +++) alsohad a higher expression of integrin or5 and β1 subunits in the tumor and its unaffected margins. CONCLUSION: FAK is a better marker for carcinogenesis and the progression of cancer than integrin or 5 or β1 subunit, and it may be not only a transformation-linkedenzyme but also a progression-linked enzyme.