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神经皮肤综合征包括多种疾病,目前认为按病理学和病因学来分类较为合适,故可分为如下四类。一、胎儿期分化异常引起皮肤和神经系统两方面病变,两者无直接联系。结节性硬化症、神经纤维瘤病、Sturge—Weber 氏病(三叉神经区域血管瘤病)等属于此类。二、由同一致病因素使皮肤和神经系统同时受损的疾病。原因有代谢异常(维生素缺乏症及内分泌疾病)、毒物、微生物(病毒、细菌、螺旋体)等。氨基酸代谢异常性疾病(包括呆小病、糙皮病、苯丙酮尿症等),粘多糖代谢异常性疾病,砷、汞及铊引起的中毒和各种微生物所致的脑膜炎等属于此类。三、由神经系统病变引起继发性皮肤病的一组疾病,包括由于神经系统损害和皮肤的营养障碍所引起的疾病,即起因于褥疮、脊髓空洞症、慢性多发性神经病、癔病及诈病的皮肤
Neurodermatosis syndrome, including a variety of diseases, is currently considered by pathology and etiology to more appropriate classification, it can be divided into the following four categories. First, the abnormal fetal differentiation caused by skin and nervous system lesions in both, there is no direct contact between the two. Tuberous sclerosis, neurofibromatosis, Sturge-Weber’s disease (trigeminal region angiomatosis) and the like fall into this category. Second, by the same pathogenic factors make the skin and nervous system damage simultaneously disease. Causes of metabolic abnormalities (vitamin deficiency and endocrine diseases), poisons, microorganisms (viruses, bacteria, spirochetes) and so on. Amino acid metabolism disorders (including asymptomatic, pellagra, phenylketonuria, etc.), mucopolysaccharidosis, arsenic, mercury and thallium poisoning and meningitis caused by various microorganisms belong to this category . Third, a group of diseases caused by nervous system diseases that cause secondary skin diseases, including diseases caused by nervous system damage and skin nutritional disorders that result from pressure ulcers, syringomyelia, chronic polyneuropathy, hysteria and malaria The skin