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应用流式细胞仪(FCM)分别对38例不同病变程度的宫颈组织(其中正常宫颈5例,宫颈非典型增生22例,宫颈浸润癌11例)的DNA含量、细胞周期各时期分布进行定量研究,结果发现随病变恶性程度的增加,其细胞内DNA指数、S期细胞比例依次增高,各组之间存在着统计学差异(P<0.05),表明细胞内DNA含量、S期细胞比例可反映肿瘤细胞的恶性潜能,可做为估计肿瘤细胞恶性潜能的辅助指标。
Flow cytometry (FCM) was used to quantitatively study the DNA content and the distribution of the cell cycle in 38 cases of different degrees of cervical tissue (including 5 cases of normal cervix, 22 cases of cervical atypical hyperplasia, 11 cases of cervical invasive carcinoma) The results showed that with the increase of the degree of malignancy, the intracellular DNA index and the proportion of S phase cells increased in turn, with statistical significance (P <0.05), indicating that intracellular DNA content, S phase cell ratio Can reflect the malignant potential of tumor cells, can be used as a secondary indicator to estimate the malignant potential of tumor cells.