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非溃疡性消化不良(NUD, non-ulcer dyspepsia)是常见症候群,其病因尚未完全明了。NUD中幽门螺旋杆菌(HP Helicobacter Pylori)相关性胃炎占很大比例。针对该菌产生之抗体反应,应用酶联免疫法(ILISA)检测了335例NUD患者血清抗-HP抗体。其中208例为经细菌培养及(或)组织学检查证实的HP相关性胃炎,对其中164例进行前瞻性随机安慰剂对照研究,以评价胶态次枸橡酸铋加氟哌酸治疗效果.治疗组与安慰剂组HP清除率分别为69％与6％(P<0.01)。HP清除后患者胃粘膜炎症好转或消除,症状明显减轻,抗-HP抗体滴度下降。
Non-ulcer dyspepsia (NUD) is a common syndrome and its etiology has not yet been fully understood. NUD in Helicobacter pylori-related gastritis accounted for a large proportion. In order to detect the antibody response of the bacteria, 335 anti-HP antibodies against NUD were detected by enzyme-linked immunosorbent assay (ELISA). Among them, 208 cases were HP-associated gastritis confirmed by bacterial culture and / or histological examination. A prospective randomized placebo-controlled study of 164 cases was conducted in order to evaluate the effect of colloidal subcutaneous administration of bismuth citrate and norfloxacin. HP clearance rates in the treatment group and the placebo group were 69% and 6%, respectively (P <0.01). After the removal of HP patients with gastric mucosal inflammation improved or eliminated, the symptoms were significantly reduced, anti-HP antibody titer decreased.