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国外用他巴唑治疗甲亢近40年,用心得安治疗甲亢近20年,国内略晚。为观察其单独应用和联合应用的疗效,我们对照观察了52例甲亢病人,以期达到最合理的用量和用法。资料与方法一、研究对象:新发现的甲亢病人52例,随机分为他巴唑组(I组)20人(男7、女13)年龄19～50岁,心得安组(Ⅱ组)10人(男4、女6)年龄20～47岁,他巴唑与心得安联合组(Ⅲ组)22人(男9、女13)年龄22～54岁。三组病人治疗前T_3、T_4、rT_3均显著高于正常,且三组病人各值间无显著差异(p>0.05),可比性强。二、方法:I组他巴唑用量45mg/日,Ⅱ组心得安用量80mg/日,Ⅲ组他巴唑用量30mg/日,心得安用量30mg/日。均不用甲状腺片,于治疗前、治疗后2周、4周分别抽血测定T_3、T_4、rT_3。
Abroad with methimazole treatment of hyperthyroidism for nearly 40 years, with the treatment of hyperthyroidism nearly 20 years, the domestic slightly later. In order to observe its curative effect of single application and combined application, we observed 52 patients with hyperthyroidism in order to achieve the most reasonable dosage and usage. Materials and Methods 1. Subjects: Totally 52 newly diagnosed patients with hyperthyroidism were randomly divided into metoprolol group (group I) 20 (male 7, female 13) aged 19 to 50 years. People (male 4, female 6) were 20 to 47 years old. 22 (male 9, female 13) aged 22 to 54 years were assigned to metoprazole and propranolol (group Ⅲ). Three groups of patients before treatment T_3, T_4, rT_3 were significantly higher than normal, and no significant difference between the three groups of patients (p> 0.05), comparable. Second, the method: I group methimazole dosage 45mg / day, the amount of propranolol group 80mg / day, group Ⅲ methimazole dosage 30mg / day, the amount of propranolol 30mg / day. None of the thyroid tablets, before treatment, 2 weeks after treatment, 4 weeks were measured blood T_3, T_4, rT_3.